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How Long Do Muscle Relaxers Stay in Your System?

How Long Do Muscle Relaxers Stay in Your System?
Picture of Medically Reviewed By: Dr. Bryon Mcquirt

Medically Reviewed By: Dr. Bryon Mcquirt

Dr. Byron McQuirt leads works closely with our addictionologist, offering holistic, evidence-based mental health and addiction care while educating future professionals.

Table of Contents

Muscle relaxers ease tight, painful muscles, yet many people worry about how long the medicine lingers in the body, whether it will surface on a drug test, and what risks follow regular use. In this article you will learn how long muscle relaxers last, how half-life works, which factors slow clearance, and when to seek outpatient drug treatment in Atlanta, GA.

What are Muscle Relaxers?

Muscle relaxers are prescription drugs that calm overactive muscles. Doctors divide them into two groups: antispasmodics for sudden spasms caused by strains or sprains, and antispasticity agents for long-term tightness, often linked to conditions like multiple sclerosis.

Common antispasticity drugs

  • Dantrolene
  • Baclofen
  • Tizanidine
  • Diazepam

Common antispasmodics

  • Carisoprodol
  • Chlorzoxazone
  • Cyclobenzaprine
  • Metaxalone
  • Methocarbamol
  • Orphenadrine

Because the United States has no over-the-counter muscle relaxers, a licensed clinician must write every prescription.

How Muscle Relaxers Work in the Body

Your brain sends electrical signals through the spinal cord, telling skeletal muscles when to contract or relax. A pulled back or pinched nerve can scramble those messages, sparking painful spasms. Muscle relaxers step in by slowing the central nervous system. That sedation interrupts wayward signals, allowing muscles to loosen and pain to drop.

Each drug follows its own timeline for absorption, metabolism, and exit. Scientists describe that journey with a single number—the half-life—the time it takes for drug concentration in the blood to fall by half.

Half-Life of Common Muscle Relaxers

Knowing half-life helps predict how long a muscle relaxer stays in your system:

Drug Type Typical Half-Life
Cyclobenzaprine (Flexeril) Antispasmodic 8 – 36 hours
Carisoprodol (Soma) → Meprobamate Antispasmodic 10 hours (can stretch to 48 hours with heavy use)
Methocarbamol (Robaxin) Antispasmodic 1 – 2 hours
Metaxalone (Skelaxin) Antispasmodic 9 hours
Baclofen Antispasticity 3 – 4 hours
Tizanidine (Zanaflex) Both 2 – 4 hours
Diazepam (Valium) Both 20 – 50 hours
Dantrolene Antispasticity 8 hours

A medicine is considered “cleared” after about five to six half-lives. Flexeril, with a half-life up to three days, might take 16 days to disappear; diazepam may persist several weeks.

Factors Affecting Duration in the Body

  • Dose and Frequency – Larger or repeated doses raise blood levels, making the drug last longer.
  • Liver and Kidney Health – These organs break down and filter medicines. Disease or damage slows removal.
  • Age and Body Composition – Older adults process drugs more slowly. High body-fat percentage can store fat-soluble medications, extending detection.
  • Metabolic Rate – A fast metabolism clears many substances quickly; a slow one keeps them around.
  • Other Drugs or Alcohol – Mixing depressants—like alcohol—with muscle relaxers taxes the liver and magnifies side effects, lengthening clearance time.

Muscle Relaxers and Drug Testing

Does a Muscle Relaxer Show Up in a Drug Test?

Standard employment panels rarely look for muscle relaxers, yet specialty tests can. Detection windows vary by sample type.

Drug Blood Urine Saliva
Baclofen Up to 72 hrs Up to 48 hrs 48 – 72 hrs
Carisoprodol / Meprobamate ~24 hrs 2 – 3 days ≤ 4 hrs
Cyclobenzaprine Up to 10 days Up to 4 days 3 – 9 days
Methocarbamol ~24 hrs 2 days ≤ 24 hrs

Hair testing can reveal use for up to 90 days, though laboratories seldom target muscle relaxers unless abuse is suspected.

Safety Considerations and Potential Risks

Even short-term prescriptions carry side effects:

  • Common effects – Drowsiness, dizziness, dry mouth, headache, nausea.
  • Flexeril-specific – Blurred vision, constipation, loss of appetite, stomach pain.

High doses or mixing with alcohol intensify dangers:

  • Extreme sedation
  • Slowed breathing
  • Low blood pressure
  • Memory problems
  • Liver stress
  • Overdose leading to seizures, hallucinations, coma, or cardiac arrest

Because diazepam and carisoprodol are controlled substances, long use can spark dependence and withdrawal.

Signs of Muscle Relaxers Addiction

More About Drug Tests and Detection

Understanding how long muscle relaxers stays in your system is only one piece of the picture. If you’d like a deeper breakdown of how urine, blood, saliva, and hair tests actually work, you can read our guide on how drug tests work. For a broader overview of different substances and timelines, visit how long drugs stay in your system.

Signs of Muscle Relaxers Addiction

  • Tolerance: needing larger amounts for relief.
  • Compulsive use: swallowing extra pills after pain fades.
  • Social withdrawal: skipping work or family events.
  • Financial strain: spending heavily on refills.
  • Risky behavior: driving while sedated.
  • Secrecy: hiding bottles, lying about dosage.
  • Mood swings: irritability when pills run low.

Spotting warning signs early allows quicker intervention.

What Are the Most Addictive Muscle Relaxers?

  • Carisoprodol (Soma) – Produces euphoria once metabolized into meprobamate.
  • Diazepam (Valium) – A long-acting benzodiazepine with high abuse potential.
  • Cyclobenzaprine (Flexeril) – Not scheduled, yet misused for its sedative buzz.
  • Methocarbamol (Robaxin) – Lower risk but still addictive if taken above guidelines.
  • Tizanidine (Zanaflex) – Least likely, though dependence can develop with misuse.

Even “safer” agents can harm when swallowed at high doses or mixed with other depressants.

Muscle Relaxer Addiction Treatment

Breaking free from muscle relaxer addiction begins with expert help. Hope Harbor Wellness delivers focused care for substance misuse and co-occurring mental health challenges, using a fully integrated treatment model.

  • Medically supervised detoxYour recovery starts with a safe, gradual taper. Our medical team oversees each step, easing withdrawal symptoms and protecting your health.
  • Evidence-based therapy – After detox, you move into a structured program tailored to your goals. Cognitive Behavioral Therapy (CBT) and Dialectical Behavior Therapy (DBT) uncover the thoughts and emotions that drive misuse. Family counseling, peer groups, and support meetings add connection and accountability, helping you rebuild trust and confidence.
  • Ongoing support – By healing both the physical and psychological sides of addiction, you gain the tools to regain control and prevent relapse.

Ready to overcome muscle relaxer abuse? Call Hope Harbor Wellness at 770-230-4257 or fill out our contact form. We’ll verify your insurance, craft a personalized plan, and guide you toward lasting stability and hope.

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